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April 25th, 2018
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Figure 1
Color fundus photographs and Fundus fluorescein angiograms (FFA) of wild -type (WT), Kimba, Akita and Akimba mice. WT mouse showed regular arterial and venular caliber, branching, and tortuosity in the retina - A–F. Kimba mice had multiple spots of hyperfluorescein (bright spots) throughout the retina - G–L. Akita mice displayed a slight increase in tortuosity with no signs of leakage - M–R. Akimba mice showed vasculature abnormalities inherited from parental strains, with high severity of leakages accompanied with tortuosity and significant loss of capillary density - S–X. Credit: Shyam Chaurasia.
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Figure 5
Loss of retinal capillary density and vessel leakage in Akimba mice. Isolectin-GS IB4 staining on retinal flat mount showed normal vascular bed and uniform capillary distribution in WT (A–C) mouse, which was reduced markedly in Kimba - D–F, Akita - G–I - and significantly higher in Akimba - J–L - mice. Disruption of the capillary network was noted especially around the optic disk of Akimba – K - retina. Credit: Shyam Chaurasia. Photo:
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